A driving force for change: interstitial flow as a morphoregulator.
Identifieur interne : 007356 ( Main/Exploration ); précédent : 007355; suivant : 007357A driving force for change: interstitial flow as a morphoregulator.
Auteurs : Joseph M. Rutkowski [Suisse] ; Melody A. SwartzSource :
- Trends in cell biology [ 1879-3088 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Facteurs chimiotactiques (métabolisme), Humains, Inflammation, Liaison aux protéines, Liquide extracellulaire (physiologie), Matrice extracellulaire (métabolisme), Matrice extracellulaire (physiologie), Microfluidique (), Modèles biologiques, Morphogenèse (physiologie), Protéines de la matrice extracellulaire (métabolisme), Transport biologique actif (physiologie), Tumeurs (métabolisme).
- MESH :
- métabolisme : Facteurs chimiotactiques, Matrice extracellulaire, Protéines de la matrice extracellulaire, Tumeurs.
- physiologie : Liquide extracellulaire, Matrice extracellulaire, Morphogenèse, Transport biologique actif.
- Animaux, Humains, Inflammation, Liaison aux protéines, Microfluidique, Modèles biologiques.
English descriptors
- KwdEn :
- Animals, Biological Transport, Active (physiology), Chemotactic Factors (metabolism), Extracellular Fluid (physiology), Extracellular Matrix (metabolism), Extracellular Matrix (physiology), Extracellular Matrix Proteins (metabolism), Humans, Inflammation, Microfluidics (methods), Models, Biological, Morphogenesis (physiology), Neoplasms (metabolism), Protein Binding.
- MESH :
- chemical , metabolism : Chemotactic Factors, Extracellular Matrix Proteins.
- metabolism : Extracellular Matrix, Neoplasms.
- methods : Microfluidics.
- physiology : Biological Transport, Active, Extracellular Fluid, Extracellular Matrix, Morphogenesis.
- Animals, Humans, Inflammation, Models, Biological, Protein Binding.
Abstract
Dynamic stresses that are present in all living tissues drive small fluid flows, called interstitial flows, through the extracellular matrix. Interstitial flow not only helps to transport nutrients throughout the tissue, but also has important roles in tissue maintenance and pathobiology that have been, until recently, largely overlooked. Here, we present evidence for the various effects of interstitial flow on cell biology, including its roles in embryonic development, tissue morphogenesis and remodeling, inflammation and lymphedema, tumor biology and immune cell trafficking. We also discuss possible mechanisms by which interstitial flow can induce morphoregulation, including direct shear stress, matrix-cell transduction (as has been proposed in the endothelial glycocalyx) and the newly emerging concept of autologous gradient formation.
DOI: 10.1016/j.tcb.2006.11.007
PubMed: 17141502
Affiliations:
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Le document en format XML
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Rutkowski</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Swartz, Melody A" sort="Swartz, Melody A" uniqKey="Swartz M" first="Melody A" last="Swartz">Melody A. Swartz</name></author></analytic><series><title level="j">Trends in cell biology</title><idno type="eISSN">1879-3088</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biological Transport, Active (physiology)</term><term>Chemotactic Factors (metabolism)</term><term>Extracellular Fluid (physiology)</term><term>Extracellular Matrix (metabolism)</term><term>Extracellular Matrix (physiology)</term><term>Extracellular Matrix Proteins (metabolism)</term><term>Humans</term><term>Inflammation</term><term>Microfluidics (methods)</term><term>Models, Biological</term><term>Morphogenesis (physiology)</term><term>Neoplasms (metabolism)</term><term>Protein Binding</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Facteurs chimiotactiques (métabolisme)</term><term>Humains</term><term>Inflammation</term><term>Liaison aux protéines</term><term>Liquide extracellulaire (physiologie)</term><term>Matrice extracellulaire (métabolisme)</term><term>Matrice extracellulaire (physiologie)</term><term>Microfluidique ()</term><term>Modèles biologiques</term><term>Morphogenèse (physiologie)</term><term>Protéines de la matrice extracellulaire (métabolisme)</term><term>Transport biologique actif (physiologie)</term><term>Tumeurs (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Chemotactic Factors</term><term>Extracellular Matrix Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Extracellular Matrix</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Microfluidics</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs chimiotactiques</term><term>Matrice extracellulaire</term><term>Protéines de la matrice extracellulaire</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Liquide extracellulaire</term><term>Matrice extracellulaire</term><term>Morphogenèse</term><term>Transport biologique actif</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Biological Transport, Active</term><term>Extracellular Fluid</term><term>Extracellular Matrix</term><term>Morphogenesis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Inflammation</term><term>Models, Biological</term><term>Protein Binding</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Inflammation</term><term>Liaison aux protéines</term><term>Microfluidique</term><term>Modèles biologiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dynamic stresses that are present in all living tissues drive small fluid flows, called interstitial flows, through the extracellular matrix. Interstitial flow not only helps to transport nutrients throughout the tissue, but also has important roles in tissue maintenance and pathobiology that have been, until recently, largely overlooked. Here, we present evidence for the various effects of interstitial flow on cell biology, including its roles in embryonic development, tissue morphogenesis and remodeling, inflammation and lymphedema, tumor biology and immune cell trafficking. We also discuss possible mechanisms by which interstitial flow can induce morphoregulation, including direct shear stress, matrix-cell transduction (as has been proposed in the endothelial glycocalyx) and the newly emerging concept of autologous gradient formation.</div></front></TEI><affiliations><list><country><li>Suisse</li></country><region><li>Canton de Vaud</li></region><settlement><li>Lausanne</li></settlement></list><tree><noCountry><name sortKey="Swartz, Melody A" sort="Swartz, Melody A" uniqKey="Swartz M" first="Melody A" last="Swartz">Melody A. Swartz</name></noCountry><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Rutkowski, Joseph M" sort="Rutkowski, Joseph M" uniqKey="Rutkowski J" first="Joseph M" last="Rutkowski">Joseph M. Rutkowski</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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